Prenol lipids
Medchemexpress LLC Tanshinone IIA sulfonate sodium | 69659-80-9 | MFCD09028094 | 396.39 | 50 MG
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, acting as an inhibitor of store-operated Ca2+ entry (SOCE), and is utilized in the treatment of cardiovascular disorders. It is intended for research use only and is not sold to patients.
- Acts as an inhibitor of store-operated Ca2+ entry (SOCE).
- Used to treat cardiovascular disorders.
- Inhibits hypoxia-induced PKG and PPAR-γ downregulation.
- Suppresses TRPC1 and TRPC6 expression and reverses suppressive effects on basal calcium concentration and SOCE in hypoxic PASMCs.
- Inhibits CYP3A4 activity.
- Attenuates scopolamine-induced cognitive dysfunctions and improves the cholinergic system.
- Increases superoxide dismutase activity and decreases oxidative stress markers.
- Alleviates hypoxia-induced changes in chronic hypoxia PH rat model.
- Prevents peritoneal adhesion.
Medchemexpress LLC Tanshinone IIA sulfonate sodium | 69659-80-9 | 396.39 | 5 MG
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA. It acts as an inhibitor of store-operated Ca2+ entry (SOCE) and is used to treat cardiovascular disorders. This product is for research use only and not sold to patients.
- Inhibits store-operated Ca2+ entry (SOCE)
- Used to treat cardiovascular disorders
- Inhibits hypoxia-induced PKG and PPAR-γ downregulation
- Suppresses TRPC1 and TRPC6 expression in hypoxic PASMCs
- Inhibits CYP3A4 activity
- Attenuates scopolamine-induced cognitive dysfunctions
- Alleviates hypoxia-induced characteristic changes in chronic hypoxia PH rat model
- Prevents peritoneal adhesion
Medchemexpress LLC Tanshinone IIB | 17397-93-2 | 310.34 | 1 MG
Tanshinone IIB is a major active constituent of the roots of Salvia miltiorrhiza (Danshen) which is widely used for the research of stroke and coronary heart disease in Asian countries. It has a neuroprotective effect via inhibition of apoptosis.
Medchemexpress LLC Tanshinone IIA anhydride | 61077-78-9 | 310.34 | 1 MG
Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor. It has Ki values of 1.9 nM for human CE1 and 1.4 nM for human intestinal CE (hiCE).
- Potent and irreversible human carboxylesterase (CE) inhibitor
- Ki values of 1.9 nM for human CE1
- Ki values of 1.4 nM for human intestinal CE (hiCE)
Medchemexpress LLC Tanshinone IIA sulfonate sodium | 69659-80-9 | 396.39 | 500 MG
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA. This compound acts as an inhibitor of store-operated Ca2+ entry (SOCE) and is primarily used in the treatment of cardiovascular disorders. It is intended for research purposes only.
- Inhibits hypoxia-induced PKG and PPAR-γ downregulation in PASMCs.
- Suppresses TRPC1 and TRPC6 expression.
- Inhibits basal calcium concentration and SOCE.
- Primarily inhibits CYP3A4 activities in vitro.
- Shows protective effects against Aβ-induced cell toxicity in SH-SY5Y cells.
- Alleviates hypoxia-induced characteristic changes in chronic hypoxia PH rat models.
- Effectively prevents peritoneal adhesion in rats.
Medchemexpress LLC Cucurbitacin IIa | 58546-34-2 | 562.73 | 1 MG
Cucurbitacin IIa, also known as Hemslecin A, is an orally active EGFR inhibitor capable of permeating the blood-brain barrier. It demonstrates an IC50 of 1.455 nM against human EGFR and exhibits anti-inflammatory activity by inhibiting the EGFR-MAPK signaling pathway.
Features and Benefits:
- Induces caspase-3-dependent apoptosis.
- Downregulates survivin expression.
- Enhances autophagy levels.
- Disrupts the actin cytoskeleton via actin aggregation.
- Arrests the cell cycle at the G2/M phase.
- Supports research into inflammation-related diseases.
- Useful in studies on depression and cancers like non-small cell lung cancer.
Medchemexpress LLC 4,4'-sulfonylbis(2-methylphenol) | 16346-97-7 | MFCD00130281 | 97.0% | 278.32 g/mol | C14H14O4S | 5 MG
This bisphenol-derived small-molecule inhibits DNA topoisomerase II alpha and is intended for research use. It demonstrates topo II inhibitory activity and in vitro cell growth inhibition, making it suitable for biochemical and anticancer studies.
- Small-molecule inhibitor of DNA topoisomerase II alpha.
- Bisphenol-derived structure; formula C14H14O4S.
- Documented in vitro topo II inhibitory activity and cell growth IC50 values.
- Supplied in small quantities for research use (5 mg pack).
- Intended for biochemical and anticancer research applications.
TARGETMOL CHEMICALS INC Cryptotanshinone 50MG
Also available in 1 mL, 10 mg, 25 mg, 100 mg and bulk. Please contact Fisher for quotes. Cryptotanshinone (Cryptotanshinon), a STAT3 inhibitor (IC50 4.6 uM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effect on STAT3 Ser727, but no inhibition for STAT1 nor STAT5. Purity 98.1%
Medchemexpress LLC Tanshinone I | 568-73-0 | MFCD00210563 | 98.8% | 276.29 g/mol | C18H12O3 | 10 MG
Analytical standard of Tanshinone I supplied as a high-purity reference material for research and analytical use. It is intended for qualitative and quantitative analysis, method development, calibration, and identity/purity testing by techniques such as liquid chromatography, gas chromatography, and mass spectrometry. Reported purity ≈98.8% and CAS 568-73-0.
- Intended for analytical applications such as LC, GC, and MS.
- High purity suitable for calibration and quantitative analysis.
- Useful for method development and identity and purity testing.
- Available in small research quantities for laboratory use.
Selleck Chemical LLC Cryptotanshinone (Tanshinone C) S2285-10mM/1mL
Cryptotanshinone (Tanshinone C) is a STAT3 inhibitor with IC50 of 4 6 M in a cell-free assay strongly inhibits phosphorylation of STAT3 Tyr705 with a small effect on STAT3 Ser727 but none against STAT1 nor STAT5 Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis
Selleck Chemical LLC Tanshinone IIA 50mg 568-72-9 Tanshinone B
Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences Tanshinone IIA United States Pharmacopeia (USP) Reference Standard | 568-72-9 | MFCD00238692 | 20MG
Tanshinone IIA United States Pharmacopeia (USP) Reference Standard | Mol Wt: 294.34 | 568-72-9 | MFCD00238692 | 20MG
